What’s your favorite poison? Alcohol, caffeine or sugar? Did you say, all three? Haha! Are the effects of caffeine and sugar really much different than alcohol? Or are they all just the same difference! See: The Big Three: Sugar, Caffeine and Alcohol
Urban Dictionary defines “same difference” as another way of saying, “Whatever”. Others define it as “no difference” or “the same, equivalent”. Here’s a dissertation on the expression: The Word Detective.